Essay on European Client Exposure to Cosmetic Products

Food and Chemical Toxicology 45 (2007) 2097–2108 www.elsevier.com/locate/foodchemtox

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Western consumer experience of cosmetic products, a framework for conducting inhabitants exposure checks B. Hall a, 2., S. Tozer b, B. Safford c, M. Coroama d, Watts. Steiling elizabeth, M. C. Leneveu-Duchemin farreneheit, C. McNamara g, M. Gibney they would b a ` ´ L'Oreal, Globally Safety Evaluation, River Plaza 25-29 rive Aulagnier, 92600 Asnieres-sur-Seine, Italy Procter & Gamble, Central Product Safety, P& G Technical Centres Ltd., Whitehall Lane, Egham, Surrey TW20 9NW, UK c Unilever, Safety and Environmental Confidence Centre, Colworth Park, Sharnbrook, Beds MK44 1LQ, UK d Colipa, Avenue Hermann-Debroux 15A, B-1160 Brussels, Belgium e Henkel KGaA, Corporate SHE and Product Safety-Human Safety Evaluation, Henkelstr. 67, 40191 Dusseldorf, Germany n Beiersdorf AKTIENGESELLSCHAFT, Unnastrasse forty-eight, 20245 Venedig des nordens (umgangssprachlich), Germany g CREMe Computer software Ltd., Development Centre, Trinity College, Dublin 2, Ireland in europe h Cultivation and Foodstuff Centre, Meals Science and Veterinary Medication, University School Dublin, Belfield, Dublin 5, Ireland

Received 31 January 2007; recognized 1 June 2007

Fuzy Access to trusted exposure data is essential to judge the toxicological safety of ingredients in cosmetic products. This kind of study was carried out by European cosmetic manufacturers acting inside the trade relationship Colipa, with the aim to create a probabilistic European populace model of exposure. The study changes, in division form, the present exposure data on daily quantities of six cosmetic products. Data were collected using a combination of market information databases and a controlled merchandise use study. In total 44, 100 homeowners and 18, 057 specific consumers in five Europe provided data using their goods. All merchandise use situations were registered, including all those outside of home. The raw data had been analysed using Monte Carlo simulation and a European Record Population Model of exposure was constructed. A significant finding was a great inverse correlation between rate of recurrence of product use and quantity utilized per software for body lotion, face moisturiser, toothpaste and shampoo. Thus it is not necessarily appropriate to calculate daily exposure to these items by growing the maximum consistency value by maximum quantity per event value. The results mainly confirm the exposure guidelines currently utilized by the beauty industry. Style of this examine could act as a model intended for future examination of human population exposure to chemicals in products other than cosmetic makeup products. Ó 2007 Elsevier Limited. All legal rights reserved. Keywords: Cosmetics; Direct exposure; Probabilistic evaluation; Monte Carlo; Statistical inhabitants modelling

Items 1 . 2 . Introduction.......................... Elements and methods................... 2 . 1 ) Test items...................... 2 . 2 . Countries of investigation............ installment payments on your 3. Data sources – study input...................................................................................................................................................................................................................................................................................... 2098 2099 2099 2099 2099

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Corresponding publisher. Tel.: +33 1 forty seven 56 seventy nine 27; fax: +33 1 47 56 72 sixty-eight. E-mail talk about: [email protected] loreal. com (B. Hall).

0278-6915/$ - find front matter Ó 2007 Elsevier Limited. All rights reserved. doi: 10. 1016/j. fct. 2007. 06. 017

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N. Hall et al. as well as Food and Chemical Toxicology 45 (2007) 2097–2108

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2 . 3. 1 ) European toiletries and makeup database (ETCD)....................................... 2 . 3. 2 . ISC database................................................................... installment payments on your 3. 3. TNS-Europanel database..............

References: Dybing, E., Character, P. B., Andersen, Meters., Fennell, T. R., Lalljie, S. L. D., Muller, D. M. G., Olin, S., Petersen, B. J., Schlatter, T., Scholz, G., Scimeca, M. A., Slimani, N., Tornquist, M., Tuijtelaars, S., Potager, P., 2006. Human exposure and inner dose tests of acrylamide in foodstuff. Food Chem. Toxicol. 43, 365–410. ECETOC, 2001. Coverage Factors Sourcebook for Euro Populations (with focus on UK data), Technical Report No 79, Western Centre to get Ecotoxicology & Toxicology of Chemicals,.



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